By Alex Avdeef
Explains the way to practice and examine the result of the newest physicochemical methods
With this publication as their consultant, readers have entry to the entire present info had to completely examine and correctly make certain a compound's pharmaceutical homes and their results on drug absorption. The ebook emphasizes oral absorption, explaining the entire physicochemical equipment used at the present time to research drug applicants. additionally, the writer presents specialist information to aid readers research the result of their reports for you to pick out the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating the entire most up-to-date study findings, tools, and assets, including:
Descriptions and functions of latest PAMPA types, drawing on greater than thirty papers released by way of the author's learn group
Two new chapters interpreting permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and strategies to help pKa determination
New examples explaining the remedy of virtually insoluble try out compounds
Additional case stories demonstrating using the newest physicochemical techniques
New, revised, and multiplied database tables through the book
Well over 2 hundred drawings aid readers larger comprehend tricky suggestions and supply a visible consultant to complicated methods. moreover, over 800 references function a gateway to the first literature within the box, facilitating extra examine into all of the subject matters lined within the book.
This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of analysis. it's also suggested as a supplemental textual content for graduate classes in pharmaceutics.
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Additional info for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef